Osteoarthritis Overtime, the build-up of homogentisic acid (HGA) leads to severe early onset osteoarthritis. HGA attacks the bones and cartilage, turning them black and brittle over time. Joints become less able to cope with activities which put them under strain,...
Black Urine The first symptom most AKU patients will experience is black or dark urine. Large quantities of a chemical called homogentisic acid (HGA) are excreted in the urine. If left to stand and exposed to the air, the HGA in urine will oxidise and start to turn...
Downloadable Resources This page provides resources for AKU patients, carers and their families. The information on this page includes leaflets about AKU and our services, impact reports, and newsletters. They are also available to download in 15 different Lanaguages....
DevelopAKUre The DevelopAKUre programme was a series of major international clinical trials, run by a consortium of 12 European partners. It aimed to study a drug, called nitisinone, and assess its effectiveness in treating AKU. The DevelopAKUre clinical trials...
Research Our ultimate goal is to cure AKU. We are committed to funding and collaborating on research into increasing our understanding of AKU and working on potential treatments and cures for the condition. Our current projects include treating nitisinone-induced...
